Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions, If you have access to journal content via a university, library or employer, sign in here, Research off-campus without worrying about access issues. The trial populations did not reflect vaccination target groups due to differences in age and restrictive trial inclusion criteria. A systematic review of available evidence: efficacy of the two vaccines against HPV, Human papillomavirus vaccination – reasons for caution. Volume 90. Journal of the Royal Society of Medicine. Will HPV vaccination prevent cervical cancer? Published by SAGE Publishing, the journals are editorially independent from the Royal Society of Medicine, and their editor is Dr Kamran Abbasi. Villa, LL, Costa, RLR, Petta, CA, Andrade, RP, Ault, KA, Giuliano, AR. Is ongoing research likely to resolve the uncertainties? Please read and accept the terms and conditions and check the box to generate a sharing link. 639–710 (November 2012) Volume 106, Issue 10. pp. Articles from this journal are generally available in PMC after a 36-month delay (embargo); however, the delay may vary at the discretion of the publisher. Will HPV vaccination prevent cervical cancer? Comment on “Will HPV vaccination prevent cervical cancer”. High efficacy against CIN1+ (CIN1, 2, 3 and adenocarcinoma in situ (AIS)) does not necessarily mean high efficacy against CIN3+ (CIN3 and AIS), which occurs much less frequently. WHO/ICO Information Centre on HPV and Cervical Cancer. Author Carole Longson. Journal of the Royal Society of Medicine Vols. Munoz, N, Kjaer, SK, Sigurdsson, K, Iversen, OE, Hernandez-Avila, M, Wheeler, CM. ICDS: ISSN: 1758-1095,1758-1095,0141-0768 Está en índices de … Women in the trials were followed up for six years or less, apart from one trial extension to just under nine years. (DOI: 10.1177/0141076819899308) by Claire P Rees, Petra Brhlikova and Allyson M Pollock, will be published by the Journal of the Royal Society of Medicine at 00:05 hrs (UK time) on Wednesday 22 January 2020. Calling for women to still attend regular cervical screening, co-author of the study, Professor Allyson Pollock, of Newcastle University, said: “We have good evidence that cervical screening significantly reduces the risk of cervical cancer in women regardless of whether they have been vaccinated.”. Simply select your manager software from the list below and click on download. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, Prevalence, incidence, and estimated life-time risk of cervical human papillomavirus infections in a nonselected finnish female population, Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections, HPV catch-up vaccination of young women: a systematic review and meta-analysis, Are the two human papillomavirus vaccines really similar? Click the button below for the full-text content, 24 hours online access to download content. About our journals. Couto, E, Saeterdal, I, Juvet, LK, Klemp, M. Di Mario, S, Basevi, V, Lopalco, PL, Balduzzi, S, D’Amico, R, Magrini, N. IARC . RSTMH founded our flagship journal Transactions of the Royal Society of Tropical Medicine & Hygiene in 1908, a year after the society itself begun. Find out about Lean Library here, If you have access to journal via a society or associations, read the instructions below. Royal Society of Medicine Today at 11:00 PM Organised by # RSMPsyc Section Integrity in research: lessons from ... the British Journal of Psychiatry 25 Feb ⌚ 6pm GMT ⭐ CPD Watch live or on-demand (T&Cs apply) Visit the RSM # Psychiatry Section homepage and scroll down to view upcoming webinars https://rsm.ac/38rpz5L See More Access: Past Subscription. JOURNAL OF THE ROYAL SOCIETY OF MEDICINEVolume 96 April 2003 1 Lythe Brow Barn, Quernmore Road, Lancaster LA2 9LZ, UK E-mail: melaniefeldman@aol.com Downloaded from jrs.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2014 Royal Society of Medicine1 Wimpole StreetLondonW1G 0AE+44 (0)20 7290 2900. Simply select your manager software from the list below and click on download. OA polices: SHERPA/RoMEO color green. By continuing to browse Royal Society Open Science. Resource information Archival Status. I have read and accept the terms and conditions, View permissions information for this article. Indexed in: Science Citation Index Expanded, Scopus, CAB Abstracts, CINAHL, EMBASE, MEDLINE. The Journal of the Royal Society of Medicine is an open peer-reviewed medical journal. Natural history of cervical intraepithelial neoplasia: a critical review, CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samples, The cervical cancer epidemic that screening has prevented in the UK, Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16–26 years: a randomised, double-blind trial, Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors, The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias, Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial, Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial, Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6.4 years, Sustained efficacy and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine up to 7.3 years in young adult women, Sustained immunogenicity and efficacy of the HPV-16/18 AS04-adjuvanted vaccine: up to 8.4 years of follow-up, Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine: final analysis of a long-term follow-up study up to 9.4 years post-vaccination, Efficacy of human papillomavirus 16/18 AS04-adjuvanted vaccine in Japanese women aged 20 to 25 years: interim analysis of a phase 2 double-blind, randomized, controlled trial, Efficacy of human papillomavirus type 16/18 AS04-adjuvanted vaccine in Japanese women aged 20 to 25 years: final analysis of a phase 2 double-blind, randomized controlled trial, Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial, Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women, Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial, Cross-protective efficacy of HPV-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by non-vaccine oncogenic HPV types: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial, Occurrence of vaccine and non-vaccine human papillomavirus types in adolescent Finnish females 4 years post-vaccination, Efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in women aged 15–25 years with and without serological evidence of previous exposure to HPV-16/18, Efficacy of human papillomavirus 16 and 18 (HPV-16/18) AS04-adjuvanted vaccine against cervical infection and precancer in young women: final event-driven analysis of the randomized, double-blind PATRICIA trial, Post hoc analysis of the PATRICIA randomized trial of the efficacy of human papillomavirus type 16 (HPV-16)/HPV-18 AS04-adjuvanted vaccine against incident and persistent infection with nonvaccine oncogenic HPV types using an alternative multiplex type-specific PCR assay for HPV DNA, Prevention of persistent human papillomavirus infection by an HPV16/18 vaccine: a community-based randomized clinical trial in Guanacaste, Costa Rica, Proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccine, Impact of human papillomavirus vaccination on cervical cytology screening, colposcopy, and treatment, Efficacy of the HPV-16/18 vaccine: final according to protocol results from the blinded phase of the randomized Costa Rica HPV-16/18 vaccine trial, Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment, Multisite HPV16/18 vaccine efficacy against cervical, anal, and oral HPV infection, Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 4-year interim follow-up of the phase 3, double-blind, randomised controlled VIVIANE study, Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 7-year follow-up of the phase 3, double-blind, randomised controlled VIVIANE study, Efficacy, immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in healthy Chinese women aged 18–25 years: results from a randomized controlled trial, Efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine in Chinese women aged 18–25 years: 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immunogenicity of human papillomavirus-16/18 AS04-adjuvanted vaccine: a randomized trial in 10–25-year-old HIV-seronegative African girls and young women, The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine HPV types in generally HPV-naive women aged 16–26 years, Serotype replacement in disease after pneumococcal vaccination, The 2010 global proficiency study of human papillomavirus genotyping in vaccinology, The serological response to papillomaviruses, Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland, Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12–13 in Scotland: retrospective population study, Trends in the sexual behaviour of 15-year olds in Scotland: 2002–14, HPV vaccination programs have not been shown to be cost-effective in countries with comprehensive Pap screening and surgery. Abstract. Use the link below to share a full-text version of this article with your friends and colleagues. We provide authors with the option to make their article gold open access in any of our journals. Cuzick’s achievements relate to the application of basic science discoveries to the practice of medicine, particularly preventive medicine. Its continuous publication history dates back to 1809. Transactions of the Royal Society of Tropical Medicine & Hygiene (TRSTMH), an official journal of the Royal Society of Tropical Medicine and Hygiene, publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine including: clinical tropical medicine infectious diseases Trials used composite surrogate outcomes which included CIN1. We use cookies to ensure that we give you the best possible experience on our website. For further information or a copy of the paper please contact: Rosalind Dewar Media Office, Royal Society of Medicine DL: +44 (0) 1580 764713 M: +44 (0) 7785 182732 E: media@rsm.ac.uk. A flurry of comments about the HPV vaccine have emerged this week, which is Cervical Cancer Prevention Week. Transactions of the Royal Society of Tropical Medicine and Hygiene. All science: Open access research. Books. If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. Does HPV vaccine prevent pre-cancerous lesions? Brown, DR, Kjaer, SK, Sigurdsson, K, Iversen, OE, Hernandez-Avila, M, Wheeler, CM. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. PVR JOURNAL. Carreon, JD, Sherman, ME, Guillen, D, Solomon, D, Herrero, R, Jeronimo, J. Peto, J, Gilham, C, Fletcher, O, Matthews, FE. There is uncertainty as to whether detected infections would clear or persist and lead to cervical changes. the site you are agreeing to our use of cookies. Supplement (Online) (DLC) 2010252215 (OCoLC)60624363 Journal of the Royal Society of Medicine. Kreimer, AR, Rodriguez, AC, Hildesheim, A, Herrero, R, Porras, C, Schiffman, M. Rodriguez, AC, Solomon, D, Herrero, R, Hildesheim, A, Gonzalez, P, Wacholder, S. Hildesheim, A, Wacholder, S, Catteau, G, Struyf, F, Dubin, G, Herrero, R. Hildesheim, A, Gonzalez, P, Kreimer, AR, Wacholder, S, Schussler, J, Rodriguez, AC. What should we do in the light of the uncertainty? Many trials diagnosed persistent infection on the basis of frequent testing at short intervals, i.e. Primary Health Care Research & Development. Volume 106, Issue 12. pp. 579–638 (October 2012) Volume 106, Issue 9. pp. Since July 2005 the editor-in-chief is Kamran Abbasi, who succeeded Robin Fox who was editor for almost 10 years. Since handing over a majority of our books list to Hodder, RSM Press are now pleased to hold a collection of carefully selected high quality publications. Create a link to share a read only version of this article with your colleagues and friends. It is the flagship journal of the Royal Society of Medicine with full editorial independence. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. See. Metrics: SJR. You can be signed in via any or all of the methods shown below at the same time. special case for case reports Medical audiences flock to the meetings at which interesting cases are presented and medical readers rapidly turn to the pages of the 'fascinoma of the month'. Published continuously since 1809, JRSM features scholarly comment and clinical research. less than six months. JRSM is an independent scientific and educational publication, which features well-argued debate on important clinical topics and, although UK-based, has articles of interest and relevance to clinicians internationally. Linking ISSN (ISSN-L): 0141-0768. Our analysis shows the trials themselves generated significant uncertainties undermining claims of efficacy in these data. Your membership -time, energy, creativity and financial support is critical to help IPVS achieve its mission! January 22, 2020 expert reaction to study looking at the effectiveness of the HPV vaccine . This site uses cookies. Looking for abbreviations of JRSM? This is just one of the many ways in which Queen Mary is continuing to push the boundaries of teaching, research and clinical practice, and helping us to achieve the previously unthinkable. LATEST NEWS. Analysis, published in the Journal of the Royal Society of Medicine, reports that the HPV vaccine may be less effective than previously thought.. Dr Gillian Knight, Associate Dean, School of Engineering & Applied Science, Aston University. Methodological factors from the trials which may affect interpretation of the results. The flagship Journal of the Royal Society of Medicine (JRSM) is one of the most widely read and enjoyed general medical periodicals, providing insight into a broad spectrum of issues facing medical The use of composite and distant surrogate outcomes makes it impossible to determine effects on clinically significant outcomes. It publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine. To find out more, read our Privacy Policy and our Cookies Policy. Romanowski, B, de Borba, PC, Naud, PS, Roteli-Martins, CM, De Carvalho, NS, Teixeira, JC. Leading the debate in clinical medicine. News. Subject: HEALTH SCIENCES. About Queen Mary University of LondonAt Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable. About this journal Published since 1809, JRSM articles range from evidence-based reviews and original research papers to commentaries and personal views. Sharing links are not available for this article. View or download all the content the society has access to. Lead researcher Dr Claire Rees, of Queen Mary University of London, said: “Trials may have overestimated efficacy by combining high-grade cervical disease with low-grade cervical changes that occur more frequently but often resolve spontaneously without progressing. The Royal Society of Medicine Collection, published by SAGE, range in scope from primary research to clinical practice, covering topics from experimental medicine to venous disease. Garland, SM, Hernandez-Avila, M, Wheeler, CM, Perez, G, Harper, DM, Leodolter, S. Munoz, N, Manalastas, R, Pitisuttithum, P, Tresukosol, D, Monsonego, J, Ault, K. Castellsague, X, Munoz, N, Pitisuttithum, P, Ferris, D, Monsonego, J, Ault, K. Yoshikawa, H, Ebihara, K, Tanaka, Y, Noda, K. Wei, L, Xie, X, Liu, J, Zhao, Y, Chen, W, Zhao, C. Tainio, K, Athanasiou, A, Tikkinen, KAO, Aaltonen, R, Cardenas, J, Hernandes. This product could help you, Accessing resources off campus can be a challenge. Journal of the Royal Society of Medicine 2020 113: 2, 64-78 Download Citation . Principal offices are located in Los Angeles, London, New Delhi, Singapore, Washington DC and Melbourne. By . Previous title: Journal of the Royal Asiatic Society of Great Britain and Ireland (New Series) (1864 - 1990) ... Prehospital and Disaster Medicine. Sara Miller McCune founded SAGE Publishing in 1965 to support the dissemination of usable knowledge and educate a global community. Join the IPVS community and enjoy many membership benefits! Human papillomavirus (HPV) vaccines as an option for preventing cervical malignancies: (how) effective and safe? https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/cervical-cancer/mortality, https://www.cdc.gov/vaccines/vpd/hpv/hcp/recommendations.html, http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000703/WC500021140.pdf, https://www.gov.uk/guidance/cervical-screening-programme-overview, https://www.uspreventiveservicestaskforce.org/Page/Document/Recommendation StatementFinal/cervical-cancer-screening#consider, https://www.isdscotland.org/Health-Topics/Cancer/Publications/2018-09-04/2018-09-04-Cervical-Screening-Report.pdf, https://www.gov.uk/government/publications/cervical-screening-primary-hpv-screening-implementation/cervical-screening-implementation-guide-for-primary-hpv-screening, Author's Response: HPV vaccination in India, Understanding HPV Disease and Prevention: A Guide for School Nurses. Of Medicine with full editorial independence and accept the terms and conditions, view information! Explore journal content Latest Issue article collections all issues will HPV vaccination prevent cervical Prevention. Eklund, C, Forslund, O, Wallin, KL, Zhou, T Dillner... In or purchase access and video in these data of Medicine1 Wimpole StreetLondonW1G 0AE+44 ( 0 ) 20 7290.... And it is journal of the Royal Society of Medicine1 Wimpole StreetLondonW1G 0AE+44 ( 0 20. What is the flagship journal of the Royal Society of Medicine Abstracts, CINAHL, EMBASE, MEDLINE select manager..., peer-reviewed articles and reviews on all aspects of Tropical Medicine and Hygiene an... Lead to cervical changes or purchase access the target vaccination groups the of. Medicine with full editorial independence instructions below energy, creativity and financial support is critical to help IPVS its! 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